IGF 1

IGF 1
Insulin like growth factor 1 - Somatomedin C IGF1 is a polypeptide hormone of the same size as insulin, or 70 amino acids, is a member of the super-family. " No, this is not the same family belongs to Clark Kent, but this family of substances identified as growth factors. It is a highly anabolic hormone released primarily in the liver (but also in peripheral tissue) to stimulate growth hormone (GH). He is responsible for most anabolic steroids, growth hormone activity, including the retention of nitrogen and protein synthesis (12), and the muscle cell hyperplasia (an increase in the number muscle cells) and mitogenesis (the growth of new muscle fibers). It can also cause hypertrophy of skeletal muscle by activating phosphatidylinositol-3-kinase (PI3K)-Akt pathway (9). Indeed, the IGF-1 acts on various tissues in order to accelerate economic growth through several mechanisms. It is also important to note that the GH and IGF-1 are linked, they produce many different effects (5). In May, you know, levels of GH and IGF, as a sharp increase during the next event, and this could be an important factor in the anabolic effects of weight training. Indeed, IGF-1 in May possibly be used as a substitute for anabolic GH (2) in many cases. IGF-1, therefore, necessary, and sufficient muscle growth (anabolic) (1) and has been shown also extremely anti-catabolic, and (2) (3). As with all anabolic substances, IGF-1 in the anabolic effects are still limited to the protein (amino acids) to the supply of muscle cells (6) (7). Thus, as might be expected, IGF works much better if you eat enough protein. IGF1 May special interest to athletes, that in May, increasing their ability to acquire new skills and techniques relevant to their sport. You see, the IGF is known neuroprotector and neuropromotor (13) (14) (15), which means that new knowledge can be learned more quickly IGF use, and for the elderly, some of the cognitive effects of aging may be staved off, or perhaps completely stopped the administration of IGF1. It also has interesting implications for the medical community, the study of Alzheimer's disease and other diseases. This is because there are IGF receptors in the brain (16) and in motor neurons (17). It should also be noted, and is of special interest to athletes and bodybuilders, to rehabbing the injury is that IGF is vital to the proper production of connective tissue, the IGF and the exogenous administration in May to improve the formation of collagen and help to repair cartilage. (19) (18). IGF is also vital for good bone density and bone density regulation (20). IGF administration May be useful for the reconstruction of a common injury suffered by athletes and bodybuilders, and would significantly reduce recovery time and increase the strength of the reconstructed area. So, now we have a basic idea that the IGF, and how it works, so I think we can think about how it works, and what results can we expect from him. Although I was a (limited) study of this complex, I found a study on the sole condition that the type of answers we seek. This study examined the injection in the complex, which is responsible for directing the expression of insulin-like growth factor I (IGF-I) in differentiated muscle fibers. Researchers found that IGF-I expression promotes an average increase of 15% of muscle mass and increase of 14% the number of young adult mice. It is gratifying to be able to save a few rooms of the complex, no? But these effects are not all that researchers have found. IGF also seems to avoid changes associated with aging in the muscle of adult mice old! These older mice had increased 27% compared to the force uninjected old muscles. Muscle mass and fiber type distributions were maintained at levels similar to those of young adults. The researchers assumed that these effects are due mainly to the stimulation of muscle regeneration via the activation of satellite cells IGF-I (8). Regardless of the mechanism of action, the results of this study is very interesting. A 15% increase in muscle mass, and 14% more, because a slight increase. Consider this if you are a typical 100 kg (220lbs) bodybuilder, you will be 115 kg (250lb) bodybuilder these types of results after the IGF-1! If you were a better Powerlift bench press that was previously effort 200kg (440lbs), we can expect to be able to bench press 500lb after IGF1! So you can not use the study on mice, to justify these numbers, but you have the idea. IGF-1 works and works very well. Even if one could reasonably expect gains of 7% of muscle mass and strength (half of the successful experience of research), the drug would be capable of many senior athletes and bodybuilders in the entire plateau endure often experienced coaches. So how can we use this equipment? Well, first of all talk about creating the ideal environment for IGF1 function. See, as you read, there is a greater interdependence and interaction between IGF, insulin and growth hormone. This has been clearly observed in studies where GH and IGF1 are used together, you get more results in the accumulation of lean body mass than when using one of them alone (10). In addition, there is a strong likelihood that testosterone would be synergistic GH (4), and increased levels of IGF in muscle (11). Let's look at the picture of what happens when you use the IGF-1, IGF-1 + GH and GH only: Changes in body weight, lean mass, fat mass, and 6 and 12 weeks after treatment. Average and 95% Cls changes. * = Significant differences compared with baseline (P <0.01). The following is the number of patients in each treatment group at 6 weeks and 12: growth hormone recombinant human and insulin-like growth factor 1 (rhGH + rhIGF-1), 13 and 9, respectively; rhGH, 12 and 11, respectively; IGF -1, 1D and 4, respectively, placebo, 14 and 11, respectively (10). As was clear from the table, you lose more fat and increase muscle combining GH and IGF-1 than either alone. The purpose of this study, 12 weeks, received around 3kgs lean mass and lost about 2kgs fat. Obviously, if we use the IGF, we want to use it with GH. And we know that GH functions best when used in combination with testosterone. And since we know that GH increases insulin sensitivity, we can take a little insulin to GH, and if we use insulin and do not want grease, I would be more comfortable if I could add the T3 as fat burner. So we have a laundry list of items needed to make the most of our use of IGF, but allows you to be honest, if you have money in the IGF (IGF and expensive stuff), then you should definitely including other items to increase its impact. Buy IGF So how do we do with the IGF? How can I buy? How much does it cost? Well, the most popular available on the black market now Lr3igf-1 (Long R3 insulin-like growth factor-I or Long R3IGF-I), which is a 83 amino acid analog human IGF-I in the composition of the of the sequence of the IGF-I with replaced by Glu Arg at position 3 (and, therefore, R3, clever name, huh?), and 13 amino acid peptide extension at the N - terminale. A? Well, that all boils down to how big I R3IGF much more potent (2-3x), as IGF-I in studies, because it has a lower affinity for the inactive IGF binding proteins (22) ( 23). Yes, everything you read on the IGF-1 still applies to this version, but only a little more active role in the body, and therefore more powerful. In addition, in substance, the type you can get your hands on now, nobody has a "small" version more. So you'll have to pay approximately $ 150.00 per 1 mg (1000mcgs/mg). How do you use? People that I mentioned earlier, I noticed what was happening between the magic 60mcgs and 120mcgs day in divided doses. In general, people who use less, and even before 50mcg/day have mediocre results. People who use others suffer headaches and nausea, and generally not much more on the way of results. References: The hormonal responses of resistance and adaptation to exercise and training. Sports Med. 2005, 35 (4) :339-361. Clinical application of insulin like growth factor I (IGF-I). Ann Intern Med. 1994 Apr 1; 120 (7) :593-601. PROTEIN muscle rupture Burnt RATS blocked IGF-I and GSK-3) (beta inhibitors. Endocrinology. 2005 Mar 31 [Epub ahead of print] Growth hormone and testosterone interact positively to increase protein and energy metabolism in men Hypopituitary. Am J Physiol Endocrinol Metab. 2005 Feb 22; [Epub ahead of print] Are the metabolic effects of GH and IGF-I separable? Growth Horm IGF Res. 2005 Feb; 15 (1) :19-27. Mr. Murphy, Plunkett LM, Gertz BJ, He W Wittreich J, Polvino WM, Clemmons DR. MK-677, orally active secretion of growth hormone, reverses the diet caused by catabolism. J Clin Endocrinol Metab. 83 (2) :320-5, 1998 Fryburg DA, Yang LA, Hill SA, Oliveras DM, Barrett EJ. Insulin and insulin-like growth factor-I improve protein anabolism in skeletal muscle during hyperaminoacidemia different mechanisms. J Clin Invest. 96 (4) :1722-9, 1995 Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function.Proc Natl Acad Sciences U.S. A. 1998 Dec 22; 95 (26) :15603-7. Molecular mechanisms modulating muscle mass. Trends Mol Med. August 2003, 9 (8) :344-50. Review. Growth Hormone recombinant human insulin-like growth factor 1 and combination therapy of AIDS-related irrational. In a double-blind, placebo-controlled trial. Ann Intern Med. 1996 Dec 1; 125 (11) :865-72. 3 Am J Physiol Endocrinol Metab. 2002 Mar; 282 (3): E601 -- Growth hormone and IGF-I in the treatment hypercatabolic patient. Baillieres Clin Endocrinol Metab. July 1996, 10 (3) :447-63. Review. IGF-I neuroprotection in the immature brain after hypoxia-ischemia, involvement of Akt and GSK3beta? Eur J Neurosci. 2005 Mar; 21 (6) :1489-502. Interdependence of estrogen and insulin-like growth factor-I in the brain: the potential for the analysis of neuroprotective mechanisms. J Endocrinol. April 2005; 185 (1) :11-7. Neuroprotective profile of gene expression in ischemic cortical cultures before IFR-1 or bFGF. Brain Res Mol Brain Res. 2004 Nov 24; 131 (1-2) :33-50. Role of the Organization of the somatotropic system in cognition and other functions of the brain. Semin Vasc Med. May 2004, 4 (2) :167-72. Review. Insulin growth factor type 1 prevents hyperglycemia-induced uncoupling protein 3 in the regulation and oxidative stress. J Neurosci Res. 15 July 2004, 77 (2) :285-91. The role of insulin-like growth factor I in response to the immature cartilage repair. Knee. April 2005, 12 (2) :113-9 Oxidative stress causes IGF-I receptor signaling disturbances in cultured human dermal fibroblasts. Mechanism of inhibition of the biosynthesis of collagen. Age-related femoral bone loss in men: evidence of hyperparathyroidism and insulin-like growth factor-1 deficiency.J Gerontol A Biol Med Sciences Phys.-Math. December 2004, 59 (12) :1285-9. Metabolic effects of human growth hormone. Metabolism. October 1995, 44 (10 Supplement 4) :33-6. IGF-I variant, which is associated with poor IGF-binding proteins show more potent and prolonged hypoglycaemic action than the IGF-I in pigs and marmoset monkeys.J Endocrinol. 1997 Nov; 155 (2) :377-86. IN VIVO IGF actions similar to a poor affinity for IGFBPs: metabolic effects and growth in pigs of different ages and GH responsiveness. Prog Growth Factor Res. 1995, 6 (2-4) :385-95. Review.